Gastro-protective potentials of Spirulina: role of vitamin B12
| Autor: | Kumudha Anantharajappa, Shylaja M. Dharmesh, Sarada Ravi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Spirulina (genus) 030109 nutrition & dietetics Antioxidant Adult male biology medicine.medical_treatment 030209 endocrinology & metabolism Pharmacology biology.organism_classification digestive system diseases Bioavailability Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Enzyme chemistry Gastro medicine Vitamin B12 Food Science |
| Zdroj: | Journal of Food Science and Technology. 57:745-753 |
| ISSN: | 0975-8402 0022-1155 |
| DOI: | 10.1007/s13197-019-04107-8 |
| Popis: | Gastric ulcer is a chronic health problem world over. Spirulina is known to contain significant amounts of vitamin B12 hence Spirulina was evaluated for gastroprotective properties against gastric ulcerations. Spirulina biomass (SB) and Spirulina extract (SE) were evaluated in swim stress induced gastric ulcers in adult male albino rats. Both SB and SE inhibited 45% and 60% of ulcers formation induced by swim stress respectively. Gastroprotection has been elucidated to be due to inhibition of (a) upregulated H+, K+-ATPase activity that induced ulcer condition; (b) lipid peroxidation and (c) altered antioxidant enzyme levels. The data highlighted the importance of vitamin B12 in protecting the gut against gastric ulcerations and suggested that both Spirulina biomass and Spirulina extract contain bioavailable B12. Spirulina based product/food can be used as alternatives to gastroprotective agents that are known to cause acidity themselves upon long term use. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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