The Regulation of Reactive Neuroblastosis, Neuroplasticity, and Nutraceuticals for Effective Management of Autism Spectrum Disorder
| Autor: | Abir Biswas, Anusuyadevi Muthuswamy, Syed Aasish Roshan, Mahesh Kandasamy, G. P. Poornimai Abirami, Esther Johnson, Vijaya Roobini Ravichandran, Suhadha Parveen, Ajisha Yesudhas, Risna Kanjirassery Radhakrishnan |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Neurogenesis Cognition Effective management medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Heterotopia (medicine) Neuroblast Autism spectrum disorder mental disorders Neuroplasticity medicine Autism Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Advances in Neurobiology ISBN: 9783030304010 |
| DOI: | 10.1007/978-3-030-30402-7_8 |
| Popis: | Autism spectrum disorder (ASD) encompasses a cluster of neurodevelopmental and genetic disorders that has been characterized mainly by social withdrawal, repetitive behavior, restricted interests, and deficits in language processing mainly in children. ASD has been known to severely impair behavioral patterns and cognitive functions including learning and memory due to defects in neuroplasticity. The biology of the ASD appears to be highly complex and heterogeneous, and thus, finding a therapeutic target for autism remains obscure. There has been no complete prevention or disease-modifying cure for this disorder. Recently, individuals with autism have been characterized by reactive neurogenesis, obstructions in axonal growth, heterotopia, resulting from dysplasia of neuroblasts in different brain regions. Therefore, it can be assumed that the aforementioned neuropathological correlates seen in the autistic individuals might originate from the defects mainly in the regulation of neuroblasts in the developing as well as adult brain. Nutrient deficiencies during early brain development and intake of certain allergic foods have been proposed as main reasons for the development of ASD. However, the integrated understanding of neurodevelopment and functional aspects of neuroplasticity working through neurogenesis in ASD is highly limited. Moreover, neurogenesis at the level of neuroblasts can be regulated by nutrition. Hence, defects in neuroblastosis underlying the severity of autism potentially could be rectified by appropriate implementation of nutraceuticals. |
| Databáze: | OpenAIRE |
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