The rôle of cortisol and β-endorphin in the response of the immune system to weaning in lambs
| Autor: | G. Palmarini, H. W. Reid, Stewart M. Rhind, S. R. McMillen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
endocrine system
medicine.medical_specialty biology business.industry animal diseases medicine.medical_treatment chemical and pharmacologic phenomena biochemical phenomena metabolism and nutrition Adrenocorticotrophic hormone Animal science Immune system Endocrinology Immunization Antigen Internal medicine biology.protein medicine Weaning Animal Science and Zoology Thyroglobulin Antibody business hormones hormone substitutes and hormone antagonists Keyhole limpet hemocyanin |
| Zdroj: | Animal Science. 66:397-402 |
| ISSN: | 1748-748X 1357-7298 |
| Popis: | The relationship between weaning stress-induced changes in stress hormone profiles and immune function was investigated in groups of 10 lambs immunized against adrenocorticotrophic hormone (ACTH; treatment A) or fi-endorphin (treatment B) to reduce the circulating concentrations of cortisol and fi-endorphin respectively. Control animals (treatment C) were immunized against a porcine thyroglobulin carrier protein. Application of weaning stress was associated with significantly elevated plasma cortisol concentrations but no significant increase in fi-endorphin concentrations in C lambs. Immunization against ACTH suppressed the post-weaning increase in cortisol concentration. This was associated with a transient reduction in the lymphocyte stimulation response to keyhole limpet haemocyanin (KLH) antigen in the A animals but there was no effect on the antibody response or interferon-y production by antigen stimulated lymphocytes. There were no significant effects of immunization against fi-endorphin on the capacity to mount antibody or cell-mediated immune responses. It is concluded that weaning stress-induced increases in cortisol did not inhibit the immune response. Since cortisol concentrations and the cell mediated immune response at 8 days after immunization were positively associated it is concluded that these indices are not independent measures of stress. |
| Databáze: | OpenAIRE |
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