| Popis: |
The use of the subarachnoid space to drug release on neural axis is an important therapeutic alternative for managing patients with chronic pain and spasticity. Intrathecal drug delivery system (IDDS) provides direct access to the central nervous system, for small and large molecules, leading to the exact site, bypassing the blood-brain barrier. The main advantage is to provide lower drug dosages near the spinal cord receptors and powerful effect compared to different administration routes, minimizing side effects. In this chapter, we are going to discuss the main aspects of IDDS and review its use in chronic pain conditions, with focus on surgical technique. |
