Studies on Effects of New Quinolones on Superoxide Production

Autor:	Rinzo Soejima, Shigenobu Umeki
Rok vydání:	1993
Předmět:	NADPH oxidase Nalidixic acid biology Chemistry Superoxide Temafloxacin General Medicine Pharmacology Tosufloxacin chemistry.chemical_compound medicine biology.protein Lomefloxacin Ofloxacin Norfloxacin medicine.drug
Zdroj:	Journal of the Japanese Association for Infectious Diseases. 67:998-1004
ISSN:	1884-569X 0387-5911
Popis:	The effects of nalidixic acid (NA) and various new quinolones, such as norfloxacin (NFLX), ofloxacin (OFLX), tosufloxacin (TFLX), lomefloxacin (LFLX) and temafloxacin (TMFX), on the superoxide production of human neutrophil NADPH oxidase were investigated. In their therapeutic concentrations, NA, NFLX and OFLX had no significant effects on superoxide generation of NADPH oxidase. However, TFLX, LFLX and TMFX increased superoxide production by about 130 percent. Fifty microM NA increased superoxide production by 130 percent. Recently, it has been reported that NA and the new quinolones have toxic side effects on the central nervous system. In this report, relationships between toxic side effects of the new quinolones and superoxide production were discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fc6c0d4db61b95e23efc074e1c6b224a https://doi.org/10.11150/kansenshogakuzasshi1970.67.998 Zobrazit plný text záznamu