Plasma and Cerebrospinal Fluid Concentrations of Morphine and Morphine Glucuronides after Oral Morphine

Autor:	P. Sandouk, A Gilton, Gilles Dhonneur, Philippe Duvaldestin, J. M. Scherrmann
Rok vydání:	1994
Předmět:	business.industry Pharmacology Blood–brain barrier Anesthesiology and Pain Medicine medicine.anatomical_structure Cerebrospinal fluid Anesthesia Renal physiology medicine Morphine In patient Respiratory system Oral morphine business Active metabolite medicine.drug
Zdroj:	Anesthesiology. 81:87-93
ISSN:	0003-3022
DOI:	10.1097/00000542-199407000-00013
Popis:	BackgroundIn patients with renal failure, morphine may cause prolonged narcosis and respiratory depression. Accumulation of the pharmacologically active metabolite mor-phine-6-glucuronlde (M-6G) may explain this effect of morphine in patients with renal failure. After a single oral dose, morphine an
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fc60887f8d724a3ee9b783cad85c68b3 https://doi.org/10.1097/00000542-199407000-00013 Zobrazit plný text záznamu