Selective distribution of β-carotene stereoisomers in rat tissues
| Autor: | Baruch Volkis, Shoshana Mokady, Ami Ben-Amotz |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Vitamin
Nutrition and Dietetics Chromatography biology Endocrinology Diabetes and Metabolism medicine.medical_treatment Carotene Spleen Dunaliella biology.organism_classification Bioavailability chemistry.chemical_compound Endocrinology medicine.anatomical_structure Biochemistry chemistry medicine Selective distribution |
| Zdroj: | Nutrition Research. 25:1005-1012 |
| ISSN: | 0271-5317 |
| Popis: | Dunaliella , a β -carotene–accumulating alga containing equal amounts of 9- cis and all- trans β -carotene stereoisomers, was compared with synthetic β -carotene composed of all- trans β -carotene with small residues of 15- cis β -carotene in rats. This study determined the bioavailability of the β -carotene stereoisomers in rats that were vitamin A depleted and fed with either Dunaliella β -carotene powder or synthetic all- trans β -carotene, both at 1 g/kg diet. Weight gain and tissue weights of rats in all groups were not different. High-performance liquid chromatography analysis for the distribution of vitamin A and carotenes in tissues and plasma showed that the original algal stereoisomers ratio of .92 was reduced in the liver and spleen to .78 and .56, respectively. The 15- cis –to–all- trans ratio in synthetic β -carotene of .05 was increased in the liver and spleen to .54 and .21, respectively. The selective distribution of β -carotene stereoisomers in rat tissues was directed to the spleen, an organ involved in immune response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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