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In the present times, international environmental regulations are earnest on the risk caused by the release of toxins into the aquatic biome; predominantly the water bodies. The discharge of active pharmaceutical compounds in the environment is found to have fatal effects on the biota of the oceanic ecosystem. The key objective of the study is to scrutinize the toxicological reprecussion of norfloxacin, an antibiotic used to treat bacterial infections which being prescribed as human medicine was found to have the possibility to pollute the water resource and sediments via input from sewage treatment plants. To explicate this study, Pangasius sp. The fish model was tested with the drug and its effects were studied thereby. This study focuses on the oxidative stress parameters which can be probed by virtue of biological markers, hormonal changes after acclimatizing the fish at suitable LC50 concentration of norfloxacin and the tissue damage assessed using histopathological analysis. The oxidative stress parameters were procured by analysis of biological markers such as Lipid peroxides, Conjugated diene, Protein sulfhydryl, Protein Carbonyl, Inorganic phosphorus, Superoxide dismutase and Catalase. The hormonal changes were studied concerning the changes in cortisol levels, which are influenced by oxidative stress. The mitigation effect and hepato-protective activity of Artemisia pallens were also studied with Norfloxacin treated fish, to imbibe the bioremediation as a strategic upfront for remediation. |
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