Multiples Myelom
| Autor: | A D Ho, T M Möhler, H. Goldschmidt, F W Cremer |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry medicine.medical_treatment Hematopoietic stem cell transplantation medicine.disease Transplantation Clinical trial medicine.anatomical_structure Internal medicine Internal Medicine medicine Combined Modality Therapy Bone marrow Stem cell business Survival rate Multiple myeloma |
| Zdroj: | Der Internist. 44:599-618 |
| ISSN: | 1432-1289 0020-9554 |
| DOI: | 10.1007/s00108-003-0920-x |
| Popis: | Multiple myeloma is one of the 20 most frequent malignancies in Germany. Initial symptoms are usually non-specific. Assessment of bone marrow and laboratory data as well as imaging techniques are essential for diagnosis and prognostic evaluation. Data from molecular cytogenetics have led to a better understanding of the pathogenesis of multiple myeloma. Cytostatic therapy with alcylating agents and glucocorticoids prolongs the survival. High-dose therapy followed by transplantation of autologous hematopoietic stem cells improves prognosis for patients up to the age of 70. Currently, modifications of allogeneic hematopoietic stem cell transplantation, anti-angiogeneic and immunomodulatory drugs as well as proteasome inhibitors are evaluated in clinical trials. Supportive care has derived benefit from the introduction of new bisphosphonates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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