| Autor: |
Mayank Jhanwar, Arun Gupta, Sanjay Mishra, Srikanth Sathagopam, Ashok Kumar, Poninder Kumar |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-256339/v1 |
| Popis: |
PurposeTo evaluate the safety and efficacy of half fluence photodynamic therapy (PDT) as treatment for symptomatic peripapillary circumscribed choroidal haemangiomas (CCHs). MethodsIn this prospective, interventional case series; 11 patients with symptomatic peripapillary CCHs presenting to a single centre were treated with half fluence PDT using verteporfin 6 mg/m2 with fluence of 25 mJ/cm2 (standard is 50 mJ/cm2) and other standard settings. Patients were evaluated at baseline, four weeks, twelve weeks and twenty-four weeks post-PDT treatment with best corrected visual acuity (BCVA), ultrasonography, spectral domain- optical coherence tomography (SD-OCT), visual evoked potential and angiographic studies. ResultsEleven patients with peripapillary CCHs received half fluence PDT. The BCVA significantly improved to 0.558 + 0.118 at four weeks post treatment (P=0.014), to 0.494 + 0.114 at twelve weeks (P=0.006) and 0.441 + 0.125 at twenty-four weeks (P=0.007) from baseline levels of 1.017 + 0.075 on log MAR scales. Similar improvement was observed in central macular thickness (CMT) of 78.50 + 13.73 um(P=0.001) at four weeks; 114.70 + 27.73 um(P=0.003) at twelve weeks and 174.60 + 23.13 um(P=0.001) at twenty-four weeks post treatment. A single session of re-treatment was required in 18%(n=2) of patients which also showed complete resolution at last follow-up. No complications were observed without any significant change in retinal nerve fibre layer (RNFL) thickness at six months follow-up(P=0.088).ConclusionsHalf fluence PDT can be an effective and safe treatment option for peripapillary CCHs which results in both anatomical and functional improvements with no observable complications. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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