The Renal Handling of Phosphate by Renal Transplant Patients: Correlation with Serum Parathyroid Hormone (SPTH), Cyclic 3′,5′-Adenosine Monophosphate (cAMP) Urinary Excretion, and Allograft Function
| Autor: | Rufino C. Pabico, H. N. Ward, Richard B. Freeman, McKenna Ba |
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| Rok vydání: | 1977 |
| Předmět: |
Adenosine monophosphate
medicine.medical_specialty business.industry Urinary system Parathyroid hormone Renal function medicine.disease Hyperphosphaturia Renal tubular acidosis Excretion chemistry.chemical_compound surgical procedures operative Endocrinology chemistry Internal medicine medicine business Hypophosphatemia |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9781461342199 |
| DOI: | 10.1007/978-1-4613-4217-5_20 |
| Popis: | Hypophosphatemia and hyperphosphaturia have been observed in renal transplant patients (1). Numerous factors can affect urinary phosphate excretion in the post-transplant state, but PTH is probably the most important. The persistence of an elevated SPTH level in the post-transplant period, despite good allograft function, suggests that phosphaturia may be directly related to the hyper-parathyroid state. Since PTH-induced phosphaturia is mediated by cAMP (2), there should be a correlation between SPTH and urinary cAMP excretion (UcAMP). Our study was initiated with the following objectives: a. To correlate the level of allograft function (determined by endogenous creatinine clearance, Ccreat) and SPTH concentration. b. To define the relationship between SPTH level and UCAMP- c. To correlate phosphate handling by the allograft with SPTH and UCAMP excretion. |
| Databáze: | OpenAIRE |
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