The Relationship between Bronchoalveolar Neutrophil Recruitment and Bronchoconstriction Induced by a Soluble Extract of Cotton Bracts1–3
| Autor: | John A. D. Cooper, William Merrill, E. N. Schachter, M G Buck |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Pulmonary and Respiratory Medicine
Bronchus Byssinosis Inhalation medicine.diagnostic_test business.industry Neutrophile Respiratory disease Chemotaxis respiratory system medicine.disease respiratory tract diseases Microbiology medicine.anatomical_structure Bronchoalveolar lavage Immunology Medicine Bronchoconstriction medicine.symptom business |
| Zdroj: | American Review of Respiratory Disease. 134:975-982 |
| ISSN: | 0003-0805 |
| DOI: | 10.1164/arrd.1986.134.5.975 |
| Popis: | Byssinosis is characterized by an obstructive bronchitis in some workers exposed to cotton dust. Mechanisms of airway alterations induced by cotton dust are unknown. To study mechanisms of these alterations, we administered an aqueous extract of cotton bract (CBE) to normal human subjects. After CBE inhalation, we demonstrated reproducible reductions in flow rates of variable magnitude. The percentage of polymorphonuclear leukocytes (PMN) recovered by bronchoalveolar lavage (BAL) and total PMN per milliliter BAL fluid were increased after challenge with CBE, and these parameters were correlated (r = 0.556 and r = 0.553, respectively) with the degree of bronchoconstriction induced by CBE. In addition, chemotactic factors for PMN were noted in BAL fluid and in supernatant from BAL cell cultures. The degree of BAL fluid chemotactic activity correlated with the degree of bronchoconstriction induced by CBE. Assessment of molecular sieve column effluent demonstrated BAL fluid to have 3 distinct peaks of chemota... |
| Databáze: | OpenAIRE |
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