Chemoenzymatic Synthesis of Enantiopure 1-Azafagomine
| Autor: | Mikael Bols, Xifu Liang |
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| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | The Journal of Organic Chemistry. 64:8485-8488 |
| ISSN: | 1520-6904 0022-3263 |
| Popis: | A new chemoenzymatic synthesis of both enantiomeric forms of the glycosidase inhibitor 1-azafagomine (1) is reported. The synthesis starts from the achiral starting materials pentadienol and methylurazol with the key steps being a hetero-Diels−Alder reaction followed by a lipase R/Novozym 435-catalyzed enantioselective esterification of the Diels−Alder adduct. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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