Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion
| Autor: | James O. Meredith, Ian M. Reaney, Mohammed Elbadawi, Mosalagae Mosalagae |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Scanning electron microscope Plastics extrusion technology industry and agriculture Sintering 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Compressive strength Phase (matter) visual_art visual_art.visual_art_medium General Materials Science Extrusion Ceramic Composite material 0210 nano-technology Porosity |
| Zdroj: | Advanced Materials Letters. 8:377-385 |
| ISSN: | 0976-397X |
| DOI: | 10.5185/amlett.2017.7063 |
| Popis: | In this study, we have developed hydroxyapatite (HA) scaffolds for synthetic bone graft from nano-sized HA particles using ceramic extrusion. We also demonstrate that these HA scaffolds show enhanced compressive strength (29.4 MPa), whilst possessing large pore sizes (> 600 µm) that are suitable for bone grafting. The extrusion process involved forming a ceramic paste by mixing the HA powder with a binder and distilled water. The ceramic paste was then fabricated using a ram extruder that was fitted with a honeycomb die to impart large, structured pores. Several green bodies were extruded and then subjected to the same drying and thermal debinding treatment. The samples underwent three different sintering temperatures and two varied dwell times, in order to determine the optimum sintering parameters. The scaffolds were then analysed for their chemical, physical, mechanical and biological properties to elucidate the effects of the sintering parameters on extruded HA scaffolds. The results revealed that the nano-sized particles exhibited a high sinterability, and XRD analysis showed phase purity until 1300 oC. At 1300 oC, trace amounts of phase impurities were detected, however, scaffolds sintered at this temperature exhibited the highest mean compressive strength. The findings demonstrated that traces of phase impurities were not detrimental to the scaffold’s compressive strength. In addition, scanning electron microscopy and density measurements revealed a highly densified solid phase was attained. |
| Databáze: | OpenAIRE |
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