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This Center is made up of an integrated set of research projects in five areas. The overall mission of the center is to utilize state-of-the-art systems biology approaches to the generation of novel therapies and diagnostics for human diseases. Drug Discovery & Delivery: Biologically relevant compounds that can be linked to effects on specific gene expression patterns, creating new drug targets. Included in this program are two new start-up companies. Cancer: Identify targets to inhibit tumor growth and cell proliferation. Neurodegenerative Disease: Investigating the disease mechanisms of several neurological disorders, including Alzheimer's, MS, Krabbe's and Parkinson's disease. Major themes include demyelination, amyloid plaque formation, and loss of cellular function. Cardio-Vascular disease; Mechanisms by which inflammatory processes associated with clinical aspiration events progress to pneumonitis and ventilator-associated pneumonias; sudden cardiac failure due to arrhythmias. Pathogenesis & Biodefense: Investigation of virulence factors for bacteria and viruses important in human disease and in bio-warfare. Novel vaccines and anti-microbial agents will be developed based on structure-function understanding of these factors. Data Intensive Core; Analysis of genomic, proteomic, epidemiological and clinical data, imaging, and modeling. |
