B-Lymphoblastic Leukemia/Lymphoma Associated with t(8;13)(p11;q12)/ZMYM2 (ZNF198)-FGFR1: Rare Case and Review of the Literature
| Autor: | Janese Trimaldi, Ling Zhang, Steven J. Agosti, Loveleen Kang, Alan F. List, Estrella M. Carballido, Bijal D. Shah, Jeremy W. Bowers, Zhong J. Zhang, Salvador Bruno, Terrence Grady, Lynn C. Moscinski, Arturo Anguiano |
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| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Myeloid medicine.diagnostic_test business.industry Hematology General Medicine medicine.disease Lymphoma Bone marrow examination stomatognathic diseases Leukemia Immunophenotyping medicine.anatomical_structure hemic and lymphatic diseases Acute myelomonocytic leukemia medicine Eosinophilia Leukocytosis medicine.symptom business |
| Zdroj: | Acta Haematologica. 130:127-134 |
| ISSN: | 1421-9662 0001-5792 |
| DOI: | 10.1159/000347030 |
| Popis: | Myeloid and lymphoid neoplasms with fibroblastic growth factor receptor-1 (FGFR1) abnormalities originate from mutated pluripotent stem cells and have a heterogeneous clinical presentation. There are 12 identified partner genes commonly involved in FGFR1 translocation at an 8p11 breakpoint. In FGFR1-related neoplasms, T-lymphoblastic lymphoma with eosinophilia is the most common clinical scenario, whereas acute B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is rare. To date, only 7 cases of B-ALL/LBL with FGFR1 abnormalities have been reported. Here, we report an additional case of a 64-year-old gentleman with leukocytosis, eosinophilia and diffuse mediastinal and general lymphadenopathy. Bone marrow examination showed patchy infiltrates of immature precursors/blasts, along with myeloid/eosinophilic hyperplasia. Immunophenotyping confirmed increased B lymphoblasts (30-40%). Karyotyping revealed cytogenetic abnormalities, including t(8;13)(p11;q12)/ZMYM2 (ZNF198)-FGFR1 and trisomy 21. The patient did not respond to hyper-CVAD chemotherapy and within 4 months developed acute myelomonocytic leukemia and expired 11 months after the initial diagnosis. Similar cases from the literature are reviewed. |
| Databáze: | OpenAIRE |
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