Synthesis and characterization of multifunctional magnetic polyvinyl alcohol (PVA) microspheres for embolization of blood vessel
| Autor: | Ning Gu, Ke Hu, Shuang Qiu, Zhao B. Guo, Jian F. Sun, Nai J. Ge, Sheng Zhao, Dong K. Sun |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
medicine.diagnostic_test medicine.medical_treatment Biomedical Engineering Magnetic separation Nanoparticle Magnetic resonance imaging 02 engineering and technology equipment and supplies 021001 nanoscience & nanotechnology Magnetic hysteresis Polyvinyl alcohol 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis medicine Magnetic nanoparticles Embolization 0210 nano-technology human activities Biomedical engineering Blood vessel |
| Zdroj: | IEEE Transactions on Biomedical Engineering. :1-1 |
| ISSN: | 1558-2531 0018-9294 |
| DOI: | 10.1109/tbme.2015.2469735 |
| Popis: | Goal: Vascular embolization has exhibited increasing significance in treatment of terminal cancer. In order to achieve better embolic effects, magnetic polyvinyl alcohol hydrogel microspheres were synthesized for magnetic field-controlled vascular embolization. Methods: Inverse suspension crosslinking method was adopted to synthesize the magnetic hydrogel microspheres by loading magnetic nanoparticles inside. The magnetic property, CT angiography, drug release, and magnetothermal performance were characterized in vitro , respectively. The fluidity of microspheres was also showed by simulation and experiment in vitro . Results: The microspheres were shown to have capability of drug loading, CT imaging, and magnetothermal behavior. Both the simulated and the experimental results exhibited that the microspheres can be controlled to aggregate in the fluid in the presence of magnetic field. Significance: The magnetic hydrogel microspheres exhibited the specific fluidity-like iodized oil, but were able to form solid embolus. Because of the advantages of this novel material, it is expected to get extensive application in the clinic embolotherapy. |
| Databáze: | OpenAIRE |
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