Synthesis and Biological Activity of Estafiatin Phosphonate Derivatives
| Autor: | A. T. Kulyyasov, R. N. Pak, S. M. Adekenov, R. I. Dzhalmakhanbetova, E. M. Suleimen |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
biology Stereochemistry Chemical modification Biological activity Achillea nobilis Plant Science General Chemistry Carbon-13 NMR Antimicrobial biology.organism_classification Sesquiterpene lactone Phosphonate General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound chemistry Organic chemistry Stereoselectivity |
| Zdroj: | Chemistry of Natural Compounds. 50:846-849 |
| ISSN: | 1573-8388 0009-3130 |
| DOI: | 10.1007/s10600-014-1097-3 |
| Popis: | Four new dialkylphosphonate derivatives 2–5 were prepared for the first time from the guaiane-type sesquiterpene lactone estafiatin (1), which was isolated from the aerial part of Achillea nobilis. Their structures were elucidated using PMR, 13C NMR, two-dimensional 1H–1H COSY, 13C–1H COLOC, and 31P–1H spectroscopy. The estafiatin phosphorylation reaction was highly chemo- and stereoselective. The antimicrobial activity of the prepared derivatives was studied. |
| Databáze: | OpenAIRE |
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