ChemInform Abstract: Novel Methods for Synthesizing 2-Chloroaldehyde from Carbonyl Compounds and Converting it into 2-Hydroxyaldehyde Derivatives

Autor:	Ken-ichi Sato, Takao Sekiguchi, Shoji Akai
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Chemistry Sulfonium General Medicine Medicinal chemistry Trifluoromethanesulfonate
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200132209
Popis:	2-Chloroaldehyde derivatives were synthesized from carbonyl compounds with [chloromethyl (dimethyl)sulfonium trifluoromethanesulfonate, ( 1 )] and DBU in THF in good yields. Further, 2-chloroaldehyde derivatives were converted into the corresponding 2-hydroxyaldehydes by treating the derivatives with n -Bu 4 NOH in good yields with the inverted configuration. The stereochemistry of all the products were determined by NMR (NOE).
Databáze:	OpenAIRE
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