The application of immobilized reagents and scavengers to multi-step organic synthesis: a total synthesis of epothilone C
| Autor: | Storer, Robert Ian |
|---|---|
| Rok vydání: | 2017 |
| DOI: | 10.17863/cam.11636 |
| Popis: | This thesis is not available on this repository until the author agrees to make it public. If you are the author of this thesis and would like to make your work openly available, please contact us: thesis@repository.cam.ac.uk. The Library can supply a digital copy for private research purposes; interested parties should submit the request form here: http://www.lib.cam.ac.uk/collections/departments/digital-content-unit/ordering-images Please note that print copies of theses may be available for consultation in the Cambridge University Library's Manuscript reading room. Admission details are at http://www.lib.cam.ac.uk/collections/departments/manuscripts-university-archives Chapter one provides an introduction to solid-phase synthesis techniques including an account of the development and integration of solid-supported reagents within multistep synthesis as a background to the project. Chapter two introduces the epothilone natural products including an explanation of the biological properties possessed by these molecules. Chapter three presents a review of previous total syntheses of the natural epothilones. Chapter four describes the results and discussion for a new total synthesis of epothilone C that applied immobilized reagents and scavengers. Chapter five provides a formal report of the experimental procedures for chapter four. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|