Serum Levels of High Sensitive C Reactive Protein in Healthy Adults From Southern Brazil
| Autor: | Ana Maria Bonametti, Cintia Magalhães Carvalho Grion, Sayonara Rangel Oliveira, Edna Maria Vissoci Reiche, Giuliana Gisele Magalhães, Francieli Delongui, Andréa Name Colado Simão, Helena Kaminami Morimoto, Ana Paula Kallaur |
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| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty biology business.industry Biochemistry (medical) Clinical Biochemistry C-reactive protein Public Health Environmental and Occupational Health Acute-phase protein Physiology Hematology High sensitive Medical Laboratory Technology Endocrinology Normal weight Healthy individuals Internal medicine biology.protein Immunology and Allergy Medicine business Risk assessment Body mass index Risk criteria |
| Zdroj: | Journal of Clinical Laboratory Analysis. 27:207-210 |
| ISSN: | 0887-8013 |
| DOI: | 10.1002/jcla.21585 |
| Popis: | Background With the emergence of more sensitive assay techniques, it has been shown that C reactive protein (CRP) is present at low levels in the serum of all the clinically healthy individuals. Objective To determine the interval values of high-sensitivity CRP (hs-CRP) in healthy adults. Methods Serum hs-CRP level was evaluated in 176 healthy blood donors. Results The serum hs-CRP level ranged from 3.0 and ≤10.0 mg. Higher hs-CRP level was observed among the female than male (P = 0.0001), and among the older than the younger individuals (P = 0.0180). Individuals with body mass index ≥25.0 kg/m2 exhibited higher hs-CRP level than those with normal weight (18.5–24.9 kg/m2; P < 0.0005). When the participants were stratified into gender and low (≤24.9 kg/m2) and high (≥24.9 kg/m2) body mass index (BMI) groups, the gender difference in hs-CRP levels remained (female with low BMI vs. male with low BMI, P = 0.0221; female with high BMI vs. male with high BMI, P = 0.0001). Conclusion Gender, age, and BMI influence serum hs-CRP level in healthy individuals and these variables should be considered for the interpretation of hs-CRP values. The results reinforce the importance in evaluating whether these differences in hs-CRP levels could contribute to alter the cardiovascular risk criteria and clinical outcomes, and whether hs-CRP thresholds for cardiovascular risk assessment should be adjusted for different gender and body mass index groups. |
| Databáze: | OpenAIRE |
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