The histochemistry of reactive masticatory muscle hypertrophy
| Autor: | Denis G.F. Harriman |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Physiology business.industry medicine.disease Masticatory muscle hypertrophy Muscles of mastication Myasthenia gravis Muscle hypertrophy Lesion Cellular and Molecular Neuroscience Endocrinology medicine.anatomical_structure Atrophy Dental disorder Physiology (medical) Internal medicine medicine Immunohistochemistry Neurology (clinical) medicine.symptom business |
| Zdroj: | Muscle & Nerve. 19:1447-1456 |
| ISSN: | 1097-4598 0148-639X |
| DOI: | 10.1002/(sici)1097-4598(199611)19:11<1447::aid-mus9>3.0.co;2-c |
| Popis: | There are two types of hypertrophy of the muscles of mastication in man: reactive hypertrophy, the more common form; and nonreactive enlargements-myositic, genetic, myopathic, and idiopathic. Reactive hypertrophy develops when the masticatory muscle workload is increased by local bone and dental disorders; such triggers are not powerful but act over long periods, thus demanding increased endurance. Exercise for endurance has a greater effect on the muscles of mastication than it has on the large muscles of the limbs; these react solely by stimulating the oxidative metabolism of type 1 fibers, whereas masticatory muscle reacts structurally by hypertrophy and progressive type 1 fiber predominance. Eventually enzyme instability of type 1 fibers and end stage atrophy of type 2 fibers may appear. Unexpectedly, lesions have also been found in control masticatory muscle, in particular type 2 fiber specific atrophy like that seen in long-standing acquired autoimmune myasthenia gravis. It is suggested that the adverse lesions in hypertrophied and control masticatory muscle are the consequence of post-activation fatigue. |
| Databáze: | OpenAIRE |
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