Lipid profile is associated with the incidence of cognitive dysfunction in viral cirrhotic patients: A data-mining analysis

Autor: Masahiro Sakata, Takumi Kawaguchi, Tetsuharu Oriishi, Minoru Itou, Eitaro Taniguchi, Michio Sata
Rok vydání: 2012
Předmět:
Zdroj: Hepatology Research. 43:418-424
ISSN: 1386-6346
DOI: 10.1111/j.1872-034x.2012.01076.x
Popis: Aim: Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We investigated the biochemical profiles associated with the incidence of CD in cirrhotic patients by using multivariate analyses, including a decision-tree algorithm. Methods: In this study, 27 viral cirrhotic patients were enrolled. All subjects underwent neuropsychiatric tests; two or more abnormal results were defined as CD. A logistic regression model was used for multivariate stepwise analysis. A decision-tree algorithm was constructed, and the categorical differences based on the decision-tree model were analyzed by χ2-tests. Results: Multivariate stepwise analysis showed the levels of total bilirubin, triglycerides and free fatty acids (FFA) as independent bioparameters associated with the incidence of CD in cirrhotic patients. The decision-tree algorithm showed that among patients with FFA of 514 mEq/L or more, 77.8% had CD. Meanwhile, among patients with FFA of less than 514 mEq/L and triglycerides of 106 mg/dL or more, 20.0% had CD. The sensitivity, specificity and accuracy for the incidence of CD using the lipid profile (FFA >514 mEq/L or triglycerides
Databáze: OpenAIRE
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