Kardiale Spättoxizität bei Morbus Hodgkin: Untersuchung mit der gepulsten Dopplerechokardiographie*
| Autor: | Klaus Schröder, Thiel E, C. Behles, Alexander Uhrig, H. Völler, Kreuser Ed, Rolf Schröder |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Chemotherapy medicine.diagnostic_test business.industry medicine.medical_treatment Hemodynamics General Medicine Disease Doppler echocardiography COPP symbols.namesake medicine.anatomical_structure ABVD Internal medicine cardiovascular system Cardiology symbols Medicine Pericardium business Doppler effect medicine.drug |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 118:247-253 |
| ISSN: | 1439-4413 0012-0472 |
| DOI: | 10.1055/s-2008-1059323 |
| Popis: | 49 patients (22 women, 27 men, mean age 43.7 [21-65] years) with Hodgkin's disease were examined by Doppler echocardiography a median of 5.37 (2-10) years after the end of chemotherapy (given according to the COPP/ABVD scheme, with or without mediastinal irradiation) for possible chronic changes in myocardium, pericardium or cardiac valves, as well as for any haemodynamic sequelae. Maximal and integrated early (E, Ei) and late (A, Ai) diastolic flow velocities and their ratio (E/A, Ei/Ai) were measured by pulsed Doppler over the mitral and tricuspid valves. Although on two-dimensional echo 21 patients (42.9%) were found to have valvar thickening, 19 (38.8%) pericardial thickening and 9 (18.4%) a reduced fibre shortening fraction, the Doppler indices were statistically not significantly different from those in 25 controls with normal hearts. These echocardiographic data of functional and morphological parameters indicate that there was no effect on various measurements of diastolic function after chemotherapy with or without mediastinal radiation. In successfully treated patients with Hodgkin's disease the described changes are of minor significance. |
| Databáze: | OpenAIRE |
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