A Cross-Sectional Population Study of Geographic, Age-Specific, and Household Risk Factors for Asymptomatic Plasmodium falciparum Malaria Infection in Western Kenya
| Autor: | Constance Tenge, Isaac Otim, Peter Odada Sumba, Sally Peprah, Steven J. Reynolds, Walter N. Wekesa, Ambrose Talisuna, Isaiah O. Genga, Joshua Biddle, Robert T. Kuremu, Pamela A. Were, Mediatrix Mumia, Tobias Kinyera, Robert J. Biggar, Kishor Bhatia, Sam M. Mbulaiteye, James J. Goedert, Ismail D. Legason, Ruth M. Pfeiffer |
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| Rok vydání: | 2019 |
| Předmět: |
Rapid diagnostic test
biology Cross-sectional study 030231 tropical medicine Plasmodium falciparum Odds ratio Logistic regression medicine.disease biology.organism_classification 03 medical and health sciences 0302 clinical medicine Infectious Diseases Virology Environmental health parasitic diseases medicine Population study Parasitology Socioeconomic status Malaria |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 100:54-65 |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | The burden of Plasmodium falciparum (Pf) malaria in Kenya is decreasing; however, it is still one of the top 10 causes of morbidity, particularly in regions of western Kenya. Between April 2015 and June 2016, we enrolled 965 apparently healthy children aged 0-15 years in former Nyanza and Western Provinces in Kenya to characterize the demographic, geographic, and household risk factors of asymptomatic malaria as part of an epidemiologic study to investigate the risk factors for endemic Burkitt lymphoma. The children were sampled using a stratified, multistage cluster sampling survey design. Malaria was assessed by rapid diagnostic test (RDT) and thick-film microscopy (TFM). Primary analyses of Pf malaria prevalence (pfPR) are based on RDT. Associations between weighted pfPR and potential risk factors were evaluated using logistic regression, accounting for the survey design. Plasmodium falciparum malaria prevalence was 36.0% (27.5%, 44.5%) by RDT and 22.3% (16.0%, 28.6%) by TFM. Plasmodium falciparum malaria prevalence was positively associated with living in the lake-endemic area (adjusted odds ratio [aOR] 3.46; 95% confidence interval [95% CI] 1.63, 7.37), paternal occupation as peasant farmer (aOR 1.87; 1.08, 3.26) or manual laborer (aOR 1.83; 1.00, 3.37), and keeping dogs (aOR 1.62; 0.98-2.69) or cows (aOR 1.52; 0.96-2.40) inside or near the household. Plasmodium falciparum malaria prevalence was inversely associated with indoor residual insecticide spraying (IRS) (aOR 0.44; 0.19, 1.01), having a household connected to electricity (aOR 0.47; 0.22, 0.98), and a household with two (aOR 0.45; 0.22, 0.93) or ≥ three rooms (aOR 0.41; 0.18, 0.93). We report high but geographically heterogeneous pfPR in children in western Kenya and significant associations with IRS and household-level socioeconomic factors. |
| Databáze: | OpenAIRE |
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