| Autor: | Repta Arnold J, Jose Alexander, Karen Engle, Paula Leppert, Margot Cortese, Joseph A. Fix |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Chromatography Stereochemistry Chemistry Organic Chemistry Pharmaceutical Science Absorption (skin) Prodrug Bioavailability Hydrolysis Rectal Absorption Rectal administration Enzymatic hydrolysis Molecular Medicine Pharmacology (medical) Alkyl Biotechnology |
| Zdroj: | Pharmaceutical Research. :501-505 |
| ISSN: | 0724-8741 |
| DOI: | 10.1023/a:1015924724973 |
| Popis: | The bioavailability of L-dopa following rectal administration of a series of short-chain alkyl esters of L-dopa was determined in rats and dogs. The esters were stable (>360 min) to hydrolysis in physiological buffer. In vitro enzymatic hydrolysis of the esters in plasma was species dependent, with the hydrolytic rate being faster in rat plasma (t1/2 600 mg/ml) esters of L-dopa are potential candidates for controlled-release rectal delivery systems designed to provide more constant plasma L-dopa levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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