Selenium supplementation for the reduction of thyroid antibodies in Hashimoto’s thyroiditis patients: a systematic review
| Autor: | Bradley Leech, Mikaila Beaver |
|---|---|
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Australian Journal of Herbal and Naturopathic Medicine. 32 |
| ISSN: | 2209-1203 2209-119X |
| Popis: | Background: Hashimoto's thyroiditis (HT) occurs when the body perceives thyroid hormones as a threat and produces antibodies against these hormones targeting thyroid cells, resulting in destruction. Selenium (Se) supplementation has been suggested to be an effective treatment for patients with HT. Objective: This systematic review aims to investigate the effectiveness of Se supplementation in reducing antibodies in adults with HT. Methods: A systematic search of the literature published until December 2019 in PubMed and CINAHL databases was conducted. Results: A total of five studies met the inclusion criteria for this review. Se supplementation (83ug to 200ug) decreased thyroid peroxidase antibodies (TPOAb) titres in adults with HT over 3 months. Four studies reported the benefits of Se supplementation for reducing TPOAbs in treated group compared to controls. One study displayed an increase in TPOAb levels with Se supplementation of 166ug daily. Discussion: This review identified the dosage, length of Se supplementation and use of levothyroxine will influence the therapeutic reduction in TPOAb. Dietary intake of Se and genetic material may also impact overall results. Se supplementation for 3 months may be beneficial in reducing TPOAb titres in adults with HT. Our results suggests dosing 200ug of Se daily combined with levothyroxine treatment is an effective method for the management of HT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|