Circulating 25-Hydroxyvitamin D and Risk of Esophageal and Gastric Cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
| Autor: | Jarmo Virtamo, Demetrius Albanes, Yong-Bing Xiang, Yu Chen, Christian C. Abnet, Wong Ho Chow, Peter T. Campbell, Kirk Snyder, Laurence N. Kolonel, Yu-Tang Gao, Mark P. Purdue, Ronald L. Horst, Loic Le Marchand, Richard B. Hayes, Wei Zheng, James M. Shikany, Kathy J. Helzlsouer, David S. Campbell, Xiao-Ou Shu, Alan A. Arslan, Kai Yu, Marjorie L. McCullough, Abraham M. Y. Nomura, Stephanie J. Weinstein |
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| Rok vydání: | 2010 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Epidemiology business.industry Case-control study Cancer Odds ratio medicine.disease Lower risk Gastroenterology vitamin D deficiency 3. Good health 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Vitamin D and neurology Medicine Risk factor business Prospective cohort study 030304 developmental biology |
| Zdroj: | American Journal of Epidemiology. 172:94-106 |
| ISSN: | 1476-6256 0002-9262 |
| DOI: | 10.1093/aje/kwq121 |
| Popis: | Upper gastrointestinal (GI) cancers of the stomach and esophagus have high incidence and mortality worldwide, but they are uncommon in Western countries. Little information exists on the association between vitamin D and risk of upper GI cancers. This study examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and upper GI cancer risk in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 1,065 upper GI cancer cases and 1,066 age-, sex-, race-, and season-of blood draw-matched controls from 8 prospective cohort studies. In multivariate-adjusted models, circulating 25(OH)D concentration was not significantly associated with upper GI cancer risk. Subgroup analysis by race showed that among Asians, but not Caucasians, lower concentrations of 25(OH)D ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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