Cytotrophoblast alterations in placentas from disorders associated with anti-phospholipid antibodies
| Autor: | Taizan Kamide, Hiroaki Aoki, Rie Kawaguchi, Akiko Konoshi, Tomohiro Tanemoto, Yukiko tanuma, Aikou Okamot, Kuniaki Oura |
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| Rok vydání: | 2014 |
| Předmět: |
Clotting factor
Pregnancy Intermediate trophoblast business.industry Cervical pregnancy Obstetrics and Gynecology Trophoblast Placental insufficiency medicine.disease Preeclampsia Andrology medicine.anatomical_structure Reproductive Medicine Placenta embryonic structures medicine business Developmental Biology |
| Zdroj: | Placenta. 35:A16 |
| ISSN: | 0143-4004 |
| DOI: | 10.1016/j.placenta.2014.08.059 |
| Popis: | s / Placenta 35 (2014) A1eA23 A16 using the QIAamp® DNA FFPE Tissue Kit (Qiagen). Bisulfite treatment was followed by MSP. DNA was amplified using the Platinum® Blue (Invitrogen). The expression of Notch1 and Dll1 was detected by IHC using EnVision method. Results: The rates of Dll1 promoter hypermethylation were significantly higher in the early-onset PE group (61.5%; 8/13) than in late-onset PE group (12.0%; 3/25; P |
| Databáze: | OpenAIRE |
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