Exploring the Association Between Emphysema Phenotypes and Low Bone Mineral Density in Smokers with and without COPD
| Autor: | Jessica González, Nerea Varo, María de los Desamparados Calleja, Aránzazu Campo, Luis M. Seijo, Patricia Restituto, Inmaculada Colina, Juan P. de-Torres, Pilar Rivera-Ortega, Ana B. Alcaide, Maria Teresa Pérez-Warnisher, Javier J. Zulueta, Macarena Rodríguez-Fraile, Juan Berto |
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| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Osteoporosis Population Pulmonary disease Logistic regression Gastroenterology Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Internal medicine medicine 030212 general & internal medicine education Bone mineral COPD education.field_of_study business.industry musculoskeletal neural and ocular physiology General Medicine respiratory system medicine.disease respiratory tract diseases Osteopenia 030228 respiratory system business |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease. 15:1823-1829 |
| ISSN: | 1178-2005 |
| DOI: | 10.2147/copd.s257918 |
| Popis: | Rationale Emphysema and osteoporosis are tobacco-related diseases. Many studies have shown that emphysema is a strong and independent predictor of low bone mineral density (BMD) in smokers; however, none of them explored its association with different emphysema subtypes. Objective To explore the association between the different emphysema subtypes and the presence of low bone mineral density in a population of active or former smokers with and without chronic obstructive pulmonary disease (COPD). Methods One hundred and fifty-three active and former smokers from a pulmonary clinic completed clinical questionnaires, pulmonary function tests, a low-dose chest computed tomography (LDCT) and a dual-energy absorptiometry (DXA) scans. Subjects were classified as having normal BMD or low BMD (osteopenia or osteoporosis). Emphysema was classified visually for its subtype and severity. Logistic regression analysis explored the relationship between the different emphysema subtypes and the presence of low BMD adjusting for other important factors. Results Seventy-five percent of the patients had low BMD (78 had osteopenia and 37 had osteoporosis). Emphysema was more frequent (66.1 vs 26.3%, p= |
| Databáze: | OpenAIRE |
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