Perioperative management of vitamin K antagonists in patients with low thromboembolic risk undergoing elective surgery: A prospective experience
| Autor: | Aldo H. Tabares, Ana Florencia Becerra, Ricardo Albertini, María Teresita Cornavaca, José I. Revigliono, Alejandro E. Contreras |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.drug_class
business.industry Anticoagulant Renal function Atrial fibrillation 030204 cardiovascular system & hematology medicine.disease Thrombosis 03 medical and health sciences 0302 clinical medicine Embolism Anesthesia medicine 030212 general & internal medicine Elective surgery Prospective cohort study Elective Surgical Procedure business |
| Zdroj: | Medicina Clínica (English Edition). 149:281-286 |
| ISSN: | 2387-0206 |
| Popis: | Background and objectives To quantify thromboembolic and bleeding events in patients with low thromboembolic risk, who were chronically receiving vitamin K antagonists and undergoing elective surgery. Material and methods A descriptive, prospective, single-centre study was conducted between December 2010 and July 2014. Patients aged over 18 years old, chronically anticoagulated with vitamin K antagonists and admitted for elective surgery were included in the study. We excluded patients with a creatinine clearance 120 kg, heparin-induced thrombocytopenia, pregnant women, carriers of an epidural catheter for analgesia, patients who underwent unscheduled surgery and high thromboembolic risk-patients. Vitamin K antagonists were discontinued 5 days prior to the procedure without administering anticoagulant enoxaparin. The NIR was measured 24 h before the procedure. A single dose of 3 mg of vitamin K was administered in cases of a NIR > 1.5. Vitamin K antagonists was resumed according to the surgical bleeding risk. Events were registered between 5 days prior to the procedure until 30 days after it. Results A total of 75 procedures were included in the study. Fifty-six patients (74.7%) received vitamin K antagonists for atrial fibrillation, 15 suffered from venous thromboembolism (20%) and 4 had mechanical heart valves (5.3%). Twenty-six patients (34.5%) underwent high-bleeding risk surgeries and 49 (65.5%) underwent low risk procedures. No thromboembolic event was recorded. Four bleeding events (5.3%) were reported, 3 of which were considered major bleeding events (2 fatal). Conclusions Suspending vitamin K antagonists with no bridging therapy performed in patients with a low thromboembolic risk does not expose such patients to a significant risk of embolic events. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect