Effect of the synthetic regulatory peptide thymohexin on the production of various classes of immunoglobulins

Autor:	A. V. Tutel'yan, Lebedev Vv, V. M. Pisarev, S. G. Kremlev
Rok vydání:	1994
Předmět:	Drug biology media_common.quotation_subject General Medicine Regulatory peptide Atopic dermatitis Thymohexin Immunoglobulin E medicine.disease Peripheral blood mononuclear cell General Biochemistry Genetics and Molecular Biology Immunology biology.protein medicine In patient Antibody media_common
Zdroj:	Bulletin of Experimental Biology and Medicine. 118:1117-1120
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02446474
Popis:	Some mechanisms of the immunoregulatory effect produced by the new drug thymohexin (immunophan), which contains synthetic hexapeptide as a pharmacological agent, are studied. Administration of the drug in a culture of polyclonally activated mononuclear cells from healthy donors intensifies IgM, IgG, and IgA production and inhibits IgE synthesis. Treating intact mononuclear cells with thymohexin does not significantly affect the production of immunoglobulins. The drug is found to intensify IgA synthesis in cases of genetically determined insufficiency and to suppress the production of IgE by lymphocytes in patients with atopic dermatitis. The immunoregulatory effect of the drug is shown to be mediated via cell-cell interaction in the system of transfer of thymohexin-activated mononuclears.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fbfc5ddc7fa2d384c22c1a3868c4b963 https://doi.org/10.1007/bf02446474 Zobrazit plný text záznamu Full text from SpringerLink