| Autor: |
Reynold Yu, Jeffrey C. Raum, Juxiang Yang, Kyoung-Jae Won, Xiaodun Yang, Gabriella Rice, Doris A. Stoffers, Junil Kim, Changhong Li, Diana E. Stanescu |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.02.28.433241 |
| Popis: |
SummaryPancreatic and duodenal homeobox 1 (PDX1)is crucial for pancreas organogenesis, yet the dynamic changes in PDX1 targets in mouse or human pancreas development have not been examined. We integrated the PDX1 cistrome with cell lineage-specific gene expression in both mouse and human developing pancreas. We identified a core set of developmentally and evolutionarily conserved PDX1 bound genes that reveal the broad multifaceted role of PDX1 in pancreas development. Despite the well-known, dramatic changes in PDX1 function and expression, we showed that PDX1 binding is largely stable from embryonic pancreas to adult islet. This may point towards a dual role of PDX1, activating or repressing the expression of its targets at different ages, dependent on other functionally-congruent or directly-interacting partners. Our work also suggests that PDX1 functions not only in initiating pancreas differentiation, but also as a potential keepsake of the progenitor program in the adult beta cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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