| Autor: |
Michael G. McHeyzer-Williams, Michael Eisenbraun, David J. Driver, Louise J. McHeyzer-Williams, Laurent Malherbe |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Advances in Experimental Medicine and Biology ISBN: 9781461352266 |
| Popis: |
Helper T cell-regulated B cell immunity constitutes a major component of the immune response to many pathogens. Spatially and temporally regulated changes in lymphocyte function and physiology underpin the primary adaptive response to antigen. We have developed flow-cytometric and single-cell RT-PCR based strategies to quantify the antigen-specific Th cell and B cell responses in non-transgenic animals directly ex vivo. Here, we will summarize our studies in the B10.BR murine response to pigeon cytochrome c (PCC) with some emphasis on the cellular complexity of the Th cell-dependent B cell response to the hapten (4-hydroxy-3-nitrophenyl)acetyl (NP). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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