Immune response toSalmonella typhi Vi-antigen and tolerance to it in T cell deprived mice
| Autor: | L. N. Fontalin, T. B. Prigozhina |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
T cell
medicine.medical_treatment Lymphokine chemical and pharmacologic phenomena General Medicine biochemical phenomena metabolism and nutrition Biology Acquired immune system General Biochemistry Genetics and Molecular Biology Thymectomy B-1 cell medicine.anatomical_structure Immune system Antigen Immunology medicine bacteria Immunologic Tolerance |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 87:38-41 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The role of T suppressors in the regulation of the immune response toSalmonella typhi Vi-antigen was studied by comparing the immune response to this antigen in T cell deprived mice (B mice) with the immune response in intact animals. Deprivation of T cells was produced by thymectomy or by lethal irradiation and subsequent injection of embryonic liver cells into the mice. The level of the immune response to Vi-antigen was almost identical in the B mice and control animals. The absence of enhancement of the immune response in the B mice shows that not only induction but also regulation of the immune response to the optimal dose of Vi-antigen is thymus-independent in character. Tolerance to Vi-antigen could be induced in B mice by means of cyclophosphamide; the degree of specific inhibition of the immune response, moreover, was the same as in animals possessing T cells. This suggests that the cause of drug-induced tolerance to this antigen is not activation of T suppressors, but rather a true deficiency of immunocompetent clones of B cells. |
| Databáze: | OpenAIRE |
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