Early continuous renal replacement therapy during infant extracorporeal life support is associated with decreased lung opacification
| Autor: | Meryle J. Eklund, John B. Cahill, Kristen Morella, James R. Kiger, David J. Annibale, Heidi J. Murphy, Jeanne G. Hill, Katherine Twombley |
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| Rok vydání: | 2019 |
| Předmět: |
Nephrology
endocrine system medicine.medical_specialty medicine.medical_treatment 0206 medical engineering Biomedical Engineering Medicine (miscellaneous) 02 engineering and technology 030204 cardiovascular system & hematology Extracorporeal Biomaterials 03 medical and health sciences 0302 clinical medicine Internal medicine Extracorporeal membrane oxygenation Medicine Renal replacement therapy business.industry Repeated measures design Retrospective cohort study Pulmonary edema medicine.disease 020601 biomedical engineering Cardiac surgery Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Artificial Organs. 22:286-293 |
| ISSN: | 1619-0904 1434-7229 |
| DOI: | 10.1007/s10047-019-01119-1 |
| Popis: | Lung opacification on chest radiography (CXR) is common during extracorporeal life support (ECLS), often resulting from pulmonary edema or inflammation. Concurrent use of continuous renal replacement therapy (CRRT) during ECLS is associated with improved fluid balance and cytokine filtration; through modification of these pathologic states, CRRT may modulate lung opacification observed on CXRs. We hypothesize that early CRRT use during infant ECLS decreases lung opacification on CXR. We conducted a retrospective cohort study comparing CXRs from infants receiving ECLS and early CRRT (n = 7) to matched infants who received ECLS alone (n = 7). The CXR obtained prior to ECLS, all CXRs obtained within the first 72 h of ECLS, and daily CXRs for the remainder of the ECLS course were analyzed. The outcome measure was the degree of opacification, determined by independent assessment of two, blinded pediatric radiologists using a modified Edwards et al.’s lung opacification scoring system (from Score 0: no opacification to Score 5: complete opacification). 220 CXRs were assessed (cases: 93, controls: 127). Inter-rater reliability was established (Cohen’s weighted к = 0.74; p |
| Databáze: | OpenAIRE |
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