Abstract P4-03-03: Lower Vitamin D Levels Are Highly Prevalent in Women with Breast Cancer
| Autor: | E Windmill, RN Moule, SP Li, Andreas Makris, M-L Seah, S Rainbow, R Bhatti, KA Steer |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Cancer Research. 70:P4-03 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.sabcs10-p4-03-03 |
| Popis: | Purpose: The objectives of this study were to determine the prevalence of vitamin D insufficiency or deficiency as measured by serum 25-hydroxyvitamin D (25-OHD) in women with breast cancer and relate this to age, ethnic group, disease stage, and seasonal variation. Methods: Levels of serum 25-OHD were requested on blood samples collected from 129 female patients with histologically-proven breast cancer (median age 61 years; range, 30-88). Vitamin D deficiency was defined as serum 25-OHD less than 12.5 nmol/L, insufficiency as 12.5 to 50 nmol/L, and sufficient levels as greater than 50 nmol/L. The prevalence of inadequate (insufficient or deficient) vitamin D levels and median 25-OHD values were calculated for the cohort as a whole and analysed according to age, ethnicity (Asian (Indian/Pakistani), White and other), disease stage (early versus metastatic), and seasons. Statistical analysis was performed using non-parametric methods and a significance level set at a two-tailed p-value < 0.05. Results: Overall 52% of women had inadequate levels of 25-OHD (45% deficient, 7% insufficient; median 29 nmol/L). There was no relationship with age. Lower levels were more common in Asian women (n=56) (64%; 16% deficient, 48% insufficient) compared with white women (n=65) (40%; all insufficient) and other (n=8) (62.5%; all insufficient). 25-OHD levels were significantly lower overall in Asian women in comparison with white women (median 36.5 versus 60 nmol/L; p=0.0002). When disease stage was considered, 54% of women with early breast cancer had inadequate 25-OHD levels (n=103) (7% deficient, 47% insufficient) in comparison with 42% of women with metastatic disease (n=26) (8% deficient, 34% insufficient) although overall levels were not significantly different between groups. There was no seasonal variation in 25-OHD levels. Conclusion: The prevalence of insufficient or deficient vitamin D levels as assessed by 25-OHD in women with breast cancer, especially in the Asian population, is high. Our findings suggest that all patients with breast cancer should have routine testing of vitamin D status and if appropriate, offered adequate vitamin D supplementation. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P4-03-03. |
| Databáze: | OpenAIRE |
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