The Effect of Ecklonia stolonifera Extracts on Blood Flow and Serum Lipid Level in Ovariectomized Rats

Autor: Sang-Hyeon Lee, Sung-Gu Kim, Yong Soo Park, Young-Kyoung Kim, Min-Hee Jeon, Mihyang Kim, Hyun-Jung Hwang, Yuck-Young Kim
Rok vydání: 2010
Předmět:
Zdroj: Journal of Life Science. 20:1851-1858
ISSN: 1225-9918
DOI: 10.5352/jls.2010.20.12.1851
Popis: Estrogen deficiency in peri- and postmenopausal women results in variety of neurovegetative, psychic and somatic symptoms, and may contribute to severe diseases within the aged female population. Ecklonia stolonifera (ES) is an edible brown algae traditionally used in fishery towns in Far East Asia. This study was performed to investigate the effects of ES extracts on blood flow and serum lipid concentration in ovariectomized rats. Weight-matched female Sprague-Dawley strain rats were assigned to four groups. Three groups were surgically ovariectomized (OVX). The fourth group was sham operated. Rats were randomly assigned to the following groups: sham-operated rats (Sham), ovariectomized control rats (OVX-CON), ovariectomized rats supplemented with ES extract at 50 mg/kg bw/day (OVX-ES50) and ovariectomized rats supplemented with ES extract at 200 mg/kg bw/day (OVX-ES200). Serum total cholesterol and triglyceride contents decreased in the sham group compared to the OVX-CON group. Six weeks feeding of ES extract resulted in a significant (p
Databáze: OpenAIRE