Proportional control of moisture content of granules by adjusting inlet air temperature in fluidized bed granulation using near-infrared spectroscopy

Autor:	Wataru Momose, Kazunari Yamashita, Tadashi Inatani, Keiichi Kuroda, Kazuhiro Sako, Maya Fujiwara
Rok vydání:	2014
Předmět:	geography Chromatography Materials science Temperature control geography.geographical_feature_category General Chemical Engineering Near-infrared spectroscopy Proportional control Inlet Granulation Mechanics of Materials Process control Particle size Composite material Water content
Zdroj:	Advanced Powder Technology. 25:704-709
ISSN:	0921-8831
DOI:	10.1016/j.apt.2013.10.013
Popis:	For process control of fluidized bed granulation process, we investigated proportional ( P ) moisture content control via adjustment of inlet air temperature in proportion to the difference between measured and target moisture content of granules. Here, we first validated P moisture content control by comparison with bed temperature control. We then confirmed that P moisture content control is effective in maintaining the moisture content, and in minimizing the variance of the particle size of granules following granulation. Furthermore, we observed that when the target temperature was higher than the measured value of inlet air temperature the P moisture content control response was accelerated. In contrast, when the target temperature was less than the measured value of inlet air temperature ( P moisture content control has good scalability and can be introduced without changing granulation conditions in the development of orally administered pharmaceutical products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fbd74b268ae61a9c6eaf688a387df614 https://doi.org/10.1016/j.apt.2013.10.013 Zobrazit plný text záznamu Full Text from ScienceDirect