Dual-wield NTPases: a novel protein family mined from AlphaFold DB
| Autor: | Koya Sakuma, Ryotaro Koike, Motonori Ota |
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| Rok vydání: | 2023 |
| DOI: | 10.1101/2023.02.19.529160 |
| Popis: | AlphaFold protein structure database (AlphaFold DB) archives a vast number of predicted models. We conducted systematic data mining against AlphaFold DB and discovered an uncharacterized P-loop NTPase family. The structure of the protein family was surprisingly novel, showing an atypical topology for P-loop NTPases, noticeable two-fold symmetry and two pairs of independent putative active sites. Our findings show that structural data mining is a powerful approach to identifying undiscovered protein families. |
| Databáze: | OpenAIRE |
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