Quinupristin-Dalfopristin–ResistantEnterococcus faeciumon Chicken and in Human Stool Specimens
| Autor: | Robert Sokolow, James A. Benson, B C Hill, L. Clifford McDonald, Yong Yu Wang, Frederick J. Angulo, Constance Mackinson, Emilio DeBess, Susan L. Johnson, Shannon Rossiter, Laura Gilbert, Maureen Sullivan |
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| Rok vydání: | 2001 |
| Předmět: |
Quinupristin
medicine.medical_treatment Streptogramin Dalfopristin General Medicine biochemical phenomena metabolism and nutrition Biology bacterial infections and mycoses biology.organism_classification Microbiology Minimum inhibitory concentration Quinupristin/dalfopristin chemistry.chemical_compound chemistry polycyclic compounds medicine Virginiamycin medicine.drug Antibacterial agent Enterococcus faecium |
| Zdroj: | New England Journal of Medicine. 345:1155-1160 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejmoa010805 |
| Popis: | Background The combination of the streptogramins quinupristin and dalfopristin was approved in the United States in late 1999 for the treatment of vancomycin-resistant Enterococcus faecium infections. Since 1974, another streptogramin, virginiamycin, has been used at subtherapeutic concentrations to promote the growth of farm animals, including chickens. Methods To determine the frequency of quinupristin-dalfopristin–resistant E. faecium, we used selective medium to culture samples from chickens purchased in supermarkets in Georgia, Maryland, Minnesota, and Oregon and stool samples from outpatients. Results Between July 1998 and June 1999, samples from 407 chickens from 26 stores in four states were cultured, as were 334 stool samples from outpatients. Quinupristin-dalfopristin–resistant E. faecium was isolated from 237 chicken carcasses and 3 stool specimens. The resistant isolates from stool had low-level resistance (minimal inhibitory concentration [MIC], 4 μg per milliliter; resistance was defined as ... |
| Databáze: | OpenAIRE |
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