Long-term outcomes of ischaemic stroke patients with diabetes in a multi-ethnic cohort in Singapore
| Autor: | Ei Zune The, Mei Yen Ng, Geelyn JL Ng, Bernadette GC Er, Amy ML Quek, Prakash Paliwal, Leonard L Yeo, Bernard PL Chan, Vijay K Sharma, Hock Luen Teoh, Eric YH Khoo, Raymond CS Seet |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Proportional hazards model business.industry Hazard ratio General Medicine 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Diabetes mellitus Internal medicine Cohort medicine Clinical endpoint business Body mass index Stroke 030217 neurology & neurosurgery Artery |
| Zdroj: | Annals of the Academy of Medicine, Singapore. 50:16-25 |
| ISSN: | 0304-4602 |
| DOI: | 10.47102/annals-acadmedsg.2020105 |
| Popis: | Introduction: Diabetes increases the risk of ischaemic stroke especially among Asians. This study aims to investigate contemporaneous long-term cardiovascular outcomes of ischaemic stroke patients with diabetes in a multi-ethnic Asian cohort. Methods: Consecutive patients with ischaemic stroke were recruited from the National University Hospital, Singapore. Data on age, gender, ethnicity, risk factors (including diabetes status and body mass index [BMI]), stroke severity and mechanisms were collected. These patients were followed up until the day of the first cardiovascular event or July 2016, whichever was earlier. The primary endpoint was the time from enrolment to the first occurrence of a composite of cerebrovascular and coronary artery events. Results: Between July 2011 and December 2013, 720 patients (mean age 60.6 years, 71% men, 43% with diabetes, median National Institute Health Stroke Severity scale 2) were enrolled and followed up. A total of 175 cardiovascular events occurred during a median follow-up of 3.25 years (6.90 events per 1,000 person-month), comprising 163 cerebrovascular and 42 coronary artery events. The adjusted hazard ratio of diabetes was 1.50 (95% CI 1.08–2.10). In a multivariable Cox proportional hazards model, Malay and Indian ethnicities, BMI |
| Databáze: | OpenAIRE |
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