Practical and Efficient Synthesis of 2-Thio-imidazole Derivative—ZY12201: A Potent TGR5 Agonist

Autor:	Mrigendra Shukla, Padmaja Pamidimukkala, Vivek M. Joshi, Vipin Chaubey, Sameer Agarwal, Bipin Pandey, Santosh Sasane, Kumar Kamlesh Singh, Shubhangi S. Soman, Hemant M. Mande, Shailesh R. Shah, Rakesh Chauhan, Sarika Jain, Kalpesh Shah, Chandrakant Sojitra
Rok vydání:	2020
Předmět:	Agonist Process development medicine.drug_class Chemistry Organic Chemistry Thio G protein-coupled bile acid receptor Combinatorial chemistry chemistry.chemical_compound ComputingMethodologies_PATTERNRECOGNITION medicine Imidazole Physical and Theoretical Chemistry Receptor Derivative (chemistry)
Zdroj:	Organic Process Research & Development. 24:1508-1514
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.0c00234
Popis:	Early scalable process development for the synthesis of ZY12201, a novel TGR5 receptor agonist, as a potential clinical candidate is described. A practical, efficient, and scalable synthetic route ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fbc348cf5143e4d8cfcc64b2ffd18f3a https://doi.org/10.1021/acs.oprd.0c00234 Zobrazit plný text záznamu