Prevention of Galactosamine-Induced Hepatic Damage by Picroliv: Study on Bile Flow and Isolated Hepatocytes (ex vivo)1
| Autor: | G. K. Patnaik, Binduja Shukla, B. N. Dhawan, P. K. S. Visen |
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| Rok vydání: | 1993 |
| Předmět: |
Pharmacology
medicine.medical_specialty Organic Chemistry Pharmaceutical Science Biology Pharmacognosy Analytical Chemistry chemistry.chemical_compound Endocrinology medicine.anatomical_structure Complementary and alternative medicine chemistry In vivo Galactosamine Internal medicine Hepatocyte Drug Discovery medicine Hepatic stellate cell Molecular Medicine Alkaline phosphatase Hepatoprotective Agent Ex vivo |
| Zdroj: | Planta Medica. 59:37-41 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2006-959600 |
| Popis: | Picroliv, a standardized extract from the plant Picrorhiza kurrooa containing active constituents, showed a significant dose dependent (3-12 mg/kg p.o. x 7) protective activity against galactosamine-induced hepatic damage in rat as evaluated on the isolated hepatocytes (ex vivo) preparation. It markedly increased the percentage of viability of hepatocytes. It also restored the galactosamine-induced changes in the levels of enzymes (GOT, GPT and alkaline phosphatase) both in isolated hepatic cells as well as in serum. In addition, picroliv possessed a marked anticholestatic effect. Picroliv was found to be more potent than silymarin, a standard hepatoprotective agent. |
| Databáze: | OpenAIRE |
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