ChemInform Abstract: Synthesis of 1,3-Diaryl-3-trifluoromethylcyclopropenes by Transition-Metal-Free Reaction of 2,2,2-Trifluoroacetophenone Tosylhydrazones with Alkynes: The Effect of the Trifluoromethyl Group

Autor:	Azucena Jiménez, M. Carmen Pérez-Aguilar, Carlos Valdés, Raquel Barroso, María-Paz Cabal
Rok vydání:	2016
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Trifluoromethyl Transition metal Base (chemistry) Chemistry Group (periodic table) General Medicine Metal catalyst Medicinal chemistry Carbene
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201627042
Popis:	1,3-Diaryl-3-trifluoromethylcyclopropenes and 2-aryl- or 2-alkyl-1,3-diaryl-3-trifluoromethylcyclopropenes are prepared in a very simple way by reaction between 1,1,1-trifluoroacetophenone tosylhydrazones and terminal or internal alkynes, respectively, in a base promoted process that does not require the presence of any metal catalyst. The essential role of the trifluoromethyl group, which enables the formation of the cyclopropenes instead of the expected pyrazoles, has been computationally investigated, suggesting the participation of a free carbene.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fbb49312fff3129e7cb94b6a2066f111 https://doi.org/10.1002/chin.201627042 Zobrazit plný text záznamu Plný text