An Overview of Models, Methods, and Reagents Developed for Translational Autoimmunity Research in the Common Marmoset (Callithrix jacchus)
| Autor: | S. Anwar Jagessar, Erwin L. A. Blezer, Jan Bauer, Bert A. 't Hart, Yolanda S. Kap, Michel P.M. Vierboom |
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| Rok vydání: | 2013 |
| Předmět: |
endocrine system
General Veterinary biology Multiple sclerosis Experimental autoimmune encephalomyelitis Arthritis Marmoset Translational research General Medicine medicine.disease medicine.disease_cause biology.organism_classification Callithrix General Biochemistry Genetics and Molecular Biology Autoimmunity Animal model biology.animal Immunology medicine Animal Science and Zoology |
| Zdroj: | Experimental Animals. 62:159-171 |
| ISSN: | 1881-7122 1341-1357 |
| DOI: | 10.1538/expanim.62.159 |
| Popis: | The common marmoset (Callithrix jacchus) is a small-bodied Neotropical primate and a useful preclinical animal model for translational research into autoimmune-mediated inflammatory diseases (AIMID), such as rheumatoid arthritis (RA) and multiple sclerosis (MS). The animal model for MS established in marmosets has proven their value for exploratory research into (etio) pathogenic mechanisms and for the evaluation of new therapies that cannot be tested in lower species because of their specificity for humans. Effective usage of the marmoset in preclinical immunological research has been hampered by the limited availability of blood for immunological studies and of reagents for profiling of cellular and humoral immune reactions. In this paper, we give a concise overview of the procedures and reagents that were developed over the years in our laboratory in marmoset models of the above-mentioned diseases. |
| Databáze: | OpenAIRE |
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