Mapping the Cerebellar Cognitive Affective Syndrome in Patients with Chronic Cerebellar Strokes
Autor: | José Ignacio Muñoz-López, Juan Fernandez-Ruiz, Lilia Nuñez-Orozco, Gabriel Ramirez-Garcia, Rosalinda Diaz, Óscar Marrufo-Meléndez, Amanda Chirino-Pérez, Carlos R. Hernandez-Castillo |
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Rok vydání: | 2021 |
Předmět: |
Cerebellum
medicine.medical_specialty Neurology medicine.diagnostic_test business.industry 05 social sciences Montreal Cognitive Assessment Magnetic resonance imaging Cognition Audiology medicine.disease Cerebellar lesions 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Cerebellar cognitive affective syndrome Medicine 0501 psychology and cognitive sciences In patient Neurology (clinical) business 030217 neurology & neurosurgery |
Zdroj: | The Cerebellum. 21:208-218 |
ISSN: | 1473-4230 |
Popis: | The cerebellar cognitive affective syndrome (CCAS) has been consistently described in patients with acute/subacute cerebellar injuries. However, studies with chronic patients have had controversial findings that have not been explored with new cerebellar-target tests, such as the CCAS scale (CCAS-S). The objective of this research is to prove and contrast the usefulness of the CCAS-S and the Montreal Cognitive Assessment (MoCA) test to evaluate cognitive/affective impairments in patients with chronic acquired cerebellar lesions, and to map the cerebellar areas whose lesions correlated with dysfunctions in these tests. CCAS-S and MoCA were administrated to 22 patients with isolated chronic cerebellar strokes and a matched comparison group. The neural bases underpinning both tests were explored with multivariate lesion-symptom mapping (LSM) methods. MoCA and CCAS-S had an adequate test performance with efficient discrimination between patients and healthy volunteers. However, only impairments determined by the CCAS-S resulted in significant regional localization within the cerebellum. Specifically, patients with chronic cerebellar lesions in right-lateralized posterolateral regions manifested cognitive impairments inherent to CCAS. These findings concurred with the anterior-sensorimotor/posterior-cognitive dichotomy in the human cerebellum and revealed clinically intra- and cross-lobular significant regions (portions of right lobule VI, VII, Crus I-II) for verbal tasks that overlap with the "language" functional boundaries in the cerebellum. Our findings prove the usefulness of MoCA and CCAS-S to reveal cognitive impairments in patients with chronic acquired cerebellar lesions. This study extends the understanding of long-term CCAS and introduces multivariate LSM methods to identify clinically intra- and cross-lobular significant regions underpinning chronic CCAS. |
Databáze: | OpenAIRE |
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