Identification of Novel α-Glucosidase Inhibitors by Screening Libraries Based on N- [4-(Benzyloxy) Benzoyl] Alanine Derivatives [1]

Autor:	R. Ahmad, Bijoy Kundu, S. K. Rastogi, A.K. Srivastava
Rok vydání:	2002
Předmět:	Alanine Serine chemistry.chemical_compound Chemistry Stereochemistry organic chemicals α glucosidase Organic Chemistry Drug Discovery General Medicine Lead compound Computer Science Applications
Zdroj:	Combinatorial Chemistry & High Throughput Screening. 5:545-550
ISSN:	1386-2073
DOI:	10.2174/1386207023330020
Popis:	A library of 72 compounds related to N- [4-(benzyloxy) benzoyl]alanine (I) was synthesized, prepared and screened for α-glucosidase inhibitory activity. Four compounds showed potent inhibition, six compounds moderate inhibition, and 16 were weak inhibitors. One compound, N- [4-(benzyloxy) benzoyl] serine, was found to be a potent inhibitor of α-glucosidase with 100% inhibition at 1μM. This inhibitor was at least five times more potent than the lead compound I.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fbaa4efb34db017530fdff0d66dcd0d2 https://doi.org/10.2174/1386207023330020 Zobrazit plný text záznamu