CHRONIC RESPIRATORY DISTRESS IN THE PREMATURE INFANT
| Autor: | Dorothy Tatter, Victor G. Mikity, Robert S. Cleland, Joan E. Hodgman |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Pediatrics
medicine.medical_specialty Lung medicine.diagnostic_test Respiratory distress business.industry medicine.disease medicine.anatomical_structure Pediatrics Perinatology and Child Health Pulmonary fibrosis Biopsy Wilson–Mikity syndrome medicine Breathing Respiratory system business Chest radiograph |
| Zdroj: | Pediatrics. 44:179-195 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.44.2.179 |
| Popis: | Thirty-four premature infants with Wilson-Mikity syndrome were seen during a 7-year period. Insidious onset of mild respiratory symptoms usually began after the first week of life. These symptoms became increasingly severe and reached maximum intensity from 4 to 8 weeks later. One quarter of the infants died during this stage. In survivors, the respiratory symptoms cleared slowly over the next months and completely disappeared in all but one infant by 2 years of age. The chest radiograph was consistent and distinctive. Diffuse, streaky infiltrate with small cystic areas appeared during the first stage and progressed as the clinical symptoms increased. The second stage was characterized by basilar hyperaeration with residual strands in the upper lobes. These changes slowly cleared as the clinical symptoms disappeared. Eleven lung biopsies were performed, and all 12 infants who died were autopsied. The pathologic picture progressed from an early, immature pattern through areas of hyperinflation and collapse in the first stage, to diffuse overinflation during the second stage. Two infants had pulmonary fibrosis. We consider the most likely pathogenesis of the syndrome to be an abnormal air distribution with a disturbance in ventilation/perfusion ratios secondary to characteristics of the immature lung. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|