Oxidation of cis ‐Diamminediacetato Pt II with Hydrogen Peroxide Can Give Rise to Two Isomeric Pt IV Products

Autor:	Dan Gibson, D. Khattib, Hana Kostrhunova, Viktor Brabec, M. Ishan, Subhendu Karmakar
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Organic Chemistry General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound Cancer cell lines Hydrogen peroxide Isomerization DNA
Zdroj:	Chemistry – A European Journal. 26:9475-9480
ISSN:	1521-3765 0947-6539
DOI:	10.1002/chem.202001472
Popis:	The oxidation of cis-[Pt(NH3 )2 (OAc)2 ] with H2 O2 yields a mixture of two isomers: ctc-[Pt(NH3 )2 (OH)2 (OAc)2 ] and ctc-[Pt(NH3 )2 (OH)(OAc)(OH)(OAc)]. Following modification with 4-phenylbutyric (PhB) anhydride, two isomers were separated and characterized; the symmetric ctc-[Pt(NH3 )2 (PhB)2 (OAc)2 ] (1) and the nonsymmetric ctc-[Pt(NH3 )2 (PhB)(OAc)(PhB)(OAc)] (2). They differ in their log P values and despite having similar cellular uptake and similar DNA platination levels, the symmetric ctc-[Pt(NH3 )2 (OH)2 (OAc)2 ] is more than 4-fold more potent than the nonsymmetric isomer in a panel of 4 cancer cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::fba28425c5f60dd6b662ef6c5d355c09 https://doi.org/10.1002/chem.202001472 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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